STRUCTURE-ACTIVITY-RELATIONSHIPS IN 1,4-BENZODIOXAN-RELATED COMPOUNDS .3. 3-PHENYL ANALOGS OF 2-[[[2-(2,6-DIMETHOXYPHENOXY)ETHYL]AMINO]-METHYL]-1,4-BENZODIOXAN (WB 4101) AS HIGHLY SELECTIVE ALPHA-1-ADRENOCEPTOR ANTAGONISTS

被引:25
作者
QUAGLIA, W
PIGINI, M
GIANNELLA, M
MELCHIORRE, C
机构
[1] UNIV CAMERINO, DEPT CHEM SCI, I-62032 CAMERINO, ITALY
[2] UNIV BOLOGNA, DEPT PHARMACEUT SCI, I-40126 BOLOGNA, ITALY
关键词
D O I
10.1021/jm00173a004
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:2946 / 2948
页数:3
相关论文
共 18 条
  • [1] SOME QUANTITATIVE USES OF DRUG ANTAGONISTS
    ARUNLAKSHANA, O
    SCHILD, HO
    [J]. BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1959, 14 (01): : 48 - 58
  • [2] RESOLUTION OF THE POTENT ALPHA-1-ADRENOCEPTOR ANTAGONIST 2-[[[2-(2,6-DIMETHOXYPHENOXY)ETHYL]AMINO]METHYL]-1,4-BENZOXATHIAN (BENOXATHIAN)
    CASSINELLI, A
    QUAGLIA, W
    BRASILI, L
    GIARDINA, D
    GULINI, U
    MELCHIORRE, C
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1987, 22 (01) : 23 - 26
  • [3] CHAPLEO CB, 1981, BRIT J PHARMACOL, V74, pP842
  • [4] ALPHA-ADRENORECEPTOR REAGENTS .2. EFFECTS OF MODIFICATION OF THE 1,4-BENZODIOXAN RING-SYSTEM ON ALPHA-ADRENORECEPTOR ACTIVITY
    CHAPLEO, CB
    MYERS, PL
    BUTLER, RCM
    DAVIS, JA
    DOXEY, JC
    HIGGINS, SD
    MYERS, M
    ROACH, AG
    SMITH, CFC
    STILLINGS, MR
    WELBOURN, AP
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (05) : 570 - 576
  • [5] FURTHER-STUDIES ON RECEPTOR INTERACTION FOR THE ALPHA-ANTAGONIST WB-4101
    KAPUR, H
    GREEN, PN
    MOTTRAM, DR
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1979, 31 (03) : 188 - 189
  • [6] The conversion of o-oxy-chalcone in flavanon. Dehydration of flavanon to flavone with phosphor pentachloride: A synthesis of flavone. (Preliminary announcement).
    Lowenbein, A
    [J]. BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1924, 57 : 1515 - 1516
  • [7] 2-[[[2-(2,6-DIMETHOXYPHENOXY)ETHYL]AMINO]-METHYL]-1,4-BENZOXATHIAN - A NEW ANTAGONIST WITH HIGH POTENCY AND SELECTIVITY TOWARD ALPHA-1-ADRENORECEPTORS
    MELCHIORRE, C
    BRASILI, L
    GIARDINA, D
    PIGINI, M
    STRAPPAGHETTI, G
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (12) : 1535 - 1536
  • [8] ADRENERGIC NEURONE BLOCKING AGENTS .2. SOME DIOXANE-SUBSTITUTED DERIVATIVES OF GUANOXAN
    MONRO, AM
    POTTER, GWH
    SEWELL, MJ
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (05) : 880 - &
  • [9] ALPHA-ADRENOCEPTOR BLOCKING EFFECTS OF A NEW BENZODIOXANE
    MOTTRAM, DR
    KAPUR, H
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1975, 27 (04) : 295 - 296
  • [10] STRUCTURE ACTIVITY RELATIONSHIPS IN 1,4-BENZODIOXAN-RELATED COMPOUNDS - INVESTIGATION ON THE ROLE OF THE DEHYDRODIOXANE RING ON ALPHA-1-ADRENORECEPTOR BLOCKING ACTIVITY
    PIGINI, M
    BRASILI, L
    GIANNELLA, M
    GIARDINA, D
    GULINI, U
    QUAGLIA, W
    MELCHIORRE, C
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (12) : 2300 - 2304