PREMALIGNANT LESIONS - ROLE OF ANTIOXIDANT VITAMINS AND BETA-CAROTENE IN RISK REDUCTION AND PREVENTION OF MALIGNANT TRANSFORMATION

被引:52
作者
SINGH, VN
GABY, SK
机构
关键词
ASCORBIC ACID; CERVICAL; DIET; DYSPLASIA; GASTRIC; LEUKOPLAKIA; METAPLASIA; PRECANCEROUS; TOCOPHEROL;
D O I
10.1093/ajcn/53.1.386S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Epidemiological studies have shown that diets rich in one or more antioxidant nutrients may reduce the risk of cancers of the lung, uterine cervix, mouth, and gastrointestinal tract. Study of premalignant lesions offers a comparatively expedient approach to identifying and evaluating the efficacy of the cancer chemopreventive components of foods. Some recent findings suggest roles for beta-carotene and/or vitamin C in reversing or reducing the risk of cervical dysplasia and oral leukoplakia. There are some indications that vitamin C and beta-carotene may reduce the risk of atrophic gastritis and gastric cancer. Additional epidemiological and molecular biology studies and clinical intervention trials using premalignant lesions as the marker of specific cancer risks should become an important component of future research in the area of cancer chemoprevention.
引用
收藏
页码:S386 / S390
页数:5
相关论文
共 60 条
  • [1] BJELKE E, 1974, SCAND J GASTROENTERO, V9, P1
  • [2] BLOCK G, 1989, NUTRITION CANCER PRE, P341
  • [3] NUTRIENTS IN DIET AND PLASMA AND RISK OF INSITU CERVICAL-CANCER
    BROCK, KE
    BERRY, G
    MOCK, PA
    MACLENNAN, R
    TRUSWELL, AS
    BRINTON, LA
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1988, 80 (08) : 580 - 585
  • [4] A CASE-CONTROL STUDY OF GASTRIC-CANCER AND DIET IN ITALY
    BUIATTI, E
    PALLI, D
    DECARLI, A
    AMADORI, D
    AVELLINI, C
    BIANCHI, S
    BISERNI, R
    CIPRIANI, F
    COCCO, P
    GIACOSA, A
    MARUBINI, E
    PUNTONI, R
    VINDIGNI, C
    FRAUMENI, J
    BLOT, W
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1989, 44 (04) : 611 - 616
  • [5] ATROPHIC GASRITIS AND VITAMIN-C STATUS IN 2 TOWNS WITH DIFFERENT STOMACH-CANCER DEATH-RATES
    BURR, ML
    SAMLOFF, IM
    BATES, CJ
    HOLLIDAY, RM
    [J]. BRITISH JOURNAL OF CANCER, 1987, 56 (02) : 163 - 167
  • [6] DURATION OF RELATIVE PROTECTION OF SCREENING FOR CERVICAL-CANCER
    CELENTANO, DD
    KLASSEN, AC
    WEISMAN, CS
    ROSENSHEIN, NB
    [J]. PREVENTIVE MEDICINE, 1989, 18 (04) : 411 - 422
  • [7] CORREA P, 1983, JNCI-J NATL CANCER I, V70, P673
  • [8] CORREA P, 1975, LANCET, V2, P58
  • [9] Correa P, 1985, DIET HUMAN CARCINOGE, P109
  • [10] CULLEN JW, 1988, CANCER, V62, P1851, DOI 10.1002/1097-0142(19881015)62:1+<1851::AID-CNCR2820621329>3.0.CO