17-BETA ESTRADIOL AFFECTS THE EXPRESSION OF GUINEA-PIG BLOOD LEUKOCYTE MHC ANTIGENS

被引：7

作者：

DEBOUT, C

LEFROITJOLIY, M

NEVEU, T

IZARD, J

机构：

[1] CHU COTE NACRE,UER MED,HISTOL LAB,F-14032 CAEN,FRANCE

[2] INST PASTEUR,INSERM 285,F-75724 PARIS 15,FRANCE

[3] ASSOC CLAUDE BERNARD,CTR IMMUNOPATHOL,INST CANC & IMMUNOGENET,F-94800 VILLEJUIF,FRANCE

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1991年 / 38卷 / 06期

关键词：

D O I：

10.1016/0960-0760(91)90080-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sex hormones have an effect on various immune responses but the mechanisms of action are unknown. One of these mechanisms might be a modification of expression of major histocompatibility complex (MHC) antigens in blood leucocytes. Estradiol-induced variations of the expression of guinea pig blood leukocytes MHC antigens (GPL-A) was studied. Class I and class II MHC antigens were detected by a sensitive rosetting method using specific alloimmune sera (AIS) and staphylococcal protein A-coated sheep red blood cells (SPA-SRBC) and evaluated by counting the number of bound SPA-SRBC per 100 cells. MHC antigens decreased after estrogen treatment. Estradiol modifies the expression of GPL-A antigens on the mononuclear cells including the Kurloff cells, which are involved in immunity or in a natural killer effect, but did not affect the expression of polymorphonuclear cells, ones which are not involved in immunity.

引用

页码：695 / 701

页数：7

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