A non-peptide neurokinin, (NK1) receptor antagonist, RP 67580, that is selective for the rodent subtype of the NK1 receptor, dose-dependently reduced plasma extravasation in the dura mater produced by electrical stimulation of the trigeminal ganglion in rats, with an ID50 of 0.6 mug kg-1. Its enantiomer RP 68651 was some 400 fold less active. The results indicate that neurogenic plasma extravasation within the dura mater is NK1 receptor-mediated and suggest that NK1 receptor antagonists may have a role as antimigraine agents.
机构:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114
BUZZI, MG
MOSKOWITZ, MA
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HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114
机构:
MASSACHUSETTS GEN HOSP, NEUROSURG & NEUROL SERV, STROKE RES LAB, BOSTON, MA 02114 USAMASSACHUSETTS GEN HOSP, NEUROSURG & NEUROL SERV, STROKE RES LAB, BOSTON, MA 02114 USA
机构:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114
BUZZI, MG
MOSKOWITZ, MA
论文数: 0引用数: 0
h-index: 0
机构:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,STROKE RES LAB,BOSTON,MA 02114
机构:
MASSACHUSETTS GEN HOSP, NEUROSURG & NEUROL SERV, STROKE RES LAB, BOSTON, MA 02114 USAMASSACHUSETTS GEN HOSP, NEUROSURG & NEUROL SERV, STROKE RES LAB, BOSTON, MA 02114 USA