HS-142-1, A NOVEL NONPEPTIDE ANP ANTAGONIST, BLOCKS AND CYCLIC-GMP PRODUCTION ELICITED BY NATRIURETIC PEPTIDES IN PC12 AND NG108-15 CELLS

被引：26

作者：

TOKI, S ^{[1
]}

MORISHITA, Y ^{[1
]}

SANO, T ^{[1
]}

MATSUDA, Y ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,3-6-6 ASAHIMACHI,MACHIDA,TOKYO 194,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 135卷 / 01期

关键词：

NATRIURETIC PEPTIDE; CYCLIC GMP FORMATION; HS-142-1; PC12; NG108-15; PARTICULATE GUANYLYL CYCLASE;

D O I：

10.1016/0304-3940(92)90149-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

HS-142-1 is a novel non-peptide antagonist for atrial natriuretic peptide (ANP) receptor. The effect of HS-142-1 on the cyclic GMP production elicited by natriuretic peptides in neuronal cell lines, PC12 and NG108-15 was examined. Natriuretic peptides such as ANP, brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) enhanced cyclic GMP production in a dose-dependent manner. HS-142-1 inhibited cyclic GMP accumulation elicited by natriuretic peptides in a dose-dependent fashion in both cells. The results suggest that HS-142-1 will be an important tool for identification and understanding of the mechanisms by which natriuretic peptides act in nervous systems.

引用

页码：117 / 120

页数：4

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