INTRACEREBRAL HALOPERIDOL POTENTIATES THE DORSAL IMMOBILITY RESPONSE IN THE RAT

被引：15

作者：

MEYER, ME

COTTRELL, GA

VANHARTESVELDT, C

机构：

[1] Department of Psychology, University of Florida, Gainesville

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 44卷 / 01期

关键词：

HALOPERIDOL; DORSAL IMMOBILITY RESPONSE; CAUDATE PUTAMEN; CORTEX; NUCLEUS ACCUMBENS; GLOBUS PALLIDUS; SUBSTANTIA-NIGRA PARS-COMPACTA;

D O I：

10.1016/0091-3057(93)90294-4

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of intracerebral microinjections of 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone(haloperidol)(1.0 mug,0.5 mul) in five regions of the brain were tested on the duration of the dorsal immobility response (DIR) and the cling and bar catalepsy in the rat. The duration of the DIR was significantly potentiated (but not the cling and bar catalepsy) following 2-h postinjection of haloperidol in the caudate putamen, nucleus accumbens, and globus pallidus but not in the substantia nigra pars compacta or cortex. These data further expand the previous evidence of regional variations in dopamine to the effects upon inhibitory behaviors.

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页码：157 / 160

页数：4

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