EFFECT OF PEPTIDASE INHIBITION ON THE PATTERN OF INTRASPINALLY RELEASED IMMUNOREACTIVE SUBSTANCE-P DETECTED WITH ANTIBODY MICROPROBES

被引：40

作者：

DUGGAN, AW ^{[1
]}

SCHAIBLE, HG ^{[1
]}

HOPE, PJ ^{[1
]}

LANG, CW ^{[1
]}

机构：

[1] UNIV WURZBURG, DEPT PHYSIOL, W-8700 WURZBURG, GERMANY

来源：

BRAIN RESEARCH | 1992年 / 579卷 / 02期

基金：

英国惠康基金;

关键词：

ANTIBODY MICROPROBE; IMMUNOREACTIVE SUBSTANCE-P RELEASE; PEPTIDASE INHIBITOR;

D O I：

10.1016/0006-8993(92)90059-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Antibody microprobes bearing antibodies to the C-terminus of substance P (SP) were used to measure release of immunoreactive (ir) SP in the dorsal horn of barbiturate anaesthetized spinal cats. Electrical stimulation of unmyelinated primary afferents of the ipsilateral tibial nerve produced a relatively localised release of ir SP in the superficial dorsal horn. Prior microinjection of the peptidase inhibitors kelatorphan and enalaprilat in the dorsal horn resulted in ir SP being detected over the whole of the dorsal horn and the overlying dorsal column. This pattern had previously been observed with evoked release of ir neurokinin A and supports the proposal that a slow degradation results in a neuropeptide accessing many sites remote from sites of release.

引用

页码：261 / 269

页数：9

共 34 条

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