THE NOVEL REDUCTION OF PYRIDINE-DERIVATIVES WITH SAMARIUM DIIODIDE

被引：31

作者：

KAMOCHI, Y

KUDO, T

机构：

[1] Daiichi College of Pharmaceutical Sciences, Minami-ku, Fukuoka, 815

来源：

HETEROCYCLES | 1993年 / 36卷 / 10期

关键词：

D O I：

10.3987/COM-93-6476

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyridine was rapidly reduced into piperidine with samarium diiodide in the presence of water at room temperature in excellent yield. On the similar reactions of pyridine derivatives bearing chloro, amino and cyano functionalities with samarium diiodide-H2O-THF system, these functionalities were partly eliminated with this system to afford pyridine or piperidine. Furthermore, pyridinecarboxamides were reduced with this system to give the corresponding methylpyridines and 2-pyridinecarboxylic acid was reduced to give 2-methylpyridine as the major products.

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页码：2383 / 2396

页数：14

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