ACTEOSIDE - A NEW ANTIHYPERTENSIVE DRUG

被引：36

作者：

AHMAD, M

RIZWANI, GH

AFTAB, K

AHMAD, VU

GILANI, AH

AHMAD, SP

机构：

[1] UNIV KARACHI,HEJ RES INST CHEM,KARACHI 75270,PAKISTAN

[2] UNIV KARACHI,DEPT PHARMACOL,KARACHI 75270,PAKISTAN

[3] AGA KHAN UNIV & MED COLL,KARACHI,PAKISTAN

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 07期

关键词：

ACTEOSIDE; SYRINGA VULGARIS; OLEACEAE; ANTIHYPERTENSIVE;

D O I：

10.1002/ptr.2650090713

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acteoside is a phenylpropanoid, reported as a chemical constituent from different plant species, and was isolated as a pure compound on RP-HPLC from the violet flowers of Syringa vulgaris. On pharmacological evaluation this compound exhibited a dose-dependent decrease in sytolic, diastolic and mean arterial blood pressure in normotensive pentothal anaesthetized rats. The median effective dose was 10 mg/kg and lasted for 2-3 min, whilst heart rate also decreased.

引用

页码：525 / 527

页数：3

共 19 条

[1]

AHMAD M, 1986, Journal of Pharmacy University of Karachi, V4, P65

[2]

AHMAD M, 1988, J CHEM SOC PAKISTAN, V10, P117

[3]

AHMAD M, 1985, THESIS ETH ZURICH, P47

[4]

AHMAD M, 1994, IN PRESS PHYTOTHER R