SUPPRESSIVE EFFECTS OF IPD-1151T (SUPLATAST-TOSILATE) ON INDUCTION OF MAST-CELLS FROM NORMAL MOUSE SPLENOCYTES

被引：14

作者：

KONNO, S ^{[1
]}

ADACHI, M ^{[1
]}

ASANO, K ^{[1
]}

GONOGAMI, Y ^{[1
]}

IKEDA, K ^{[1
]}

OKAMOTO, K ^{[1
]}

TAKAHASHI, T ^{[1
]}

机构：

[1] SHOWA UNIV,SCH MED,DEPT MED BIOL,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 01期

关键词：

MAST CELL; CYTOLOGY; DRUG EFFECT; ANTIALLERGIC DRUG;

D O I：

10.1016/0014-2999(94)90151-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of IPD-1151T (suplatast-tosilate) on murine mast cell induction was examined by in vitro cell culture. Splenocytes from BALB/c mice suspended in RPMI-1640 medium supplemented with interleukin-3 were cultured in the presence or absence of IPD-1151T. Half of the total volume of the medium was changed every 4-5 days. The number of mast cells increased with culture time and reached a peak on the 16th day when the cells were cultured without IPD-1151T. However, the growth of mast cells from the splenocyte culture was dose dependently inhibited by IPD-1151T. Furthermore, IPD-1151T inhibited the proliferation of mast cell progenitor cells, IC-2, but not that of splenocytes or mature mast cells.

引用

页码：15 / 20

页数：6

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