AN EFFICIENT AND STEREOSPECIFIC SYNTHESIS OF NOVEL PYRAZINE C-NUCLEOSIDES

被引：23

作者：

CHEN, JJ

WALKER, JA

LIU, WM

WISE, DS

TOWNSEND, LB

机构：

[1] UNIV MICHIGAN, COLL LITERATURE SCI & ARTS, DEPT CHEM, ANN ARBOR, MI 48109 USA

[2] UNIV MICHIGAN, COLL PHARM, DEPT MED CHEM, ANN ARBOR, MI 48109 USA

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 46期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)01826-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel 2'-deoxy-beta-D-ribofuranosyl pyrazine C-nucleoside (6) was synthesized via a stereospecific palladium(0)-mediated cross-coupling reaction. The beta-configuration of this nucleoside was established by NOE analysis and the formation of a 5,5'-anhydro nucleoside 5. The compound 4a, obtained via the cross-coupling reaction and selective deprotection, is a versatile intermediate for the preparation of other pyrazine C-nucleoside analogues.

引用

页码：8363 / 8366

页数：4

共 15 条

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