HUMORAL IMMUNE-RESPONSE IN INFANTS AFTER BCG VACCINATION

被引：32

作者：

BEYAZOVA, U ^{[1
]}

ROTA, S ^{[1
]}

CEVHEROGLU, C ^{[1
]}

KARSLIGIL, T ^{[1
]}

机构：

[1] GAZI UNIV,FAC MED,DEPT MICROBIOL,ANKARA,TURKEY

来源：

TUBERCLE AND LUNG DISEASE | 1995年 / 76卷 / 03期

关键词：

D O I：

10.1016/S0962-8479(05)80013-9

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Setting: Child welfare division of a university-based department of pediatrics in Turkey. Objective: To determine specific IgM and IgG response after BCG vaccination. Design: Prospective, randomized trial. Methods: Serum samples of 66 infants were taken before and at 2, 4, 6 and 15 months after vaccination. 35 infants were vaccinated at the first month and 31 at the second month after delivery. An ELISA assay was performed using PPD antigen. Results: IgM antibodies increased significantly (P < 0.05) during the post-vaccination period. On the other hand IgG antibodies decreased in the second month after vaccination. At the fourth month the IgG level began to rise continuously (P < 0.01). The infants who were vaccinated at the second month showed a higher IgM response at the second and fourth month than those vaccinated in the first month (P < 0.05), but the difference was not visible thereafter (P > 0.05). 52 infants (78%) were tuberculin positive 8 weeks after vaccination. Conclusion: Anti-PPD IgM and IgG levels rise progressively in BCG-vaccinated infants.

引用

页码：248 / 253

页数：6

共 21 条

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