DISTRIBUTION OF MISONIDAZOLE IN HUMAN-TUMORS AND NORMAL-TISSUES

Levels of misonidazole in human tumours, normal tissues and blood have been measured in patients given a lg oral dose of drug before surgery or biopsy. The results show that 50-70% of the blood level was found in a wide range of tumours and that similar levels were found in adjacent normal tissues.Good penetration of drug was achieved within tumours, and up to 90-100% of the blood level was found in the necrotic cyst fluid at the centre of some tumours. CSF studies showed free diffusion into the GNS, which was confirmed by finding 50-70% of the blood level within brain tumours. A delay of passage of drugs into the CSF was noted, which was not found for drug diffusion into bile and saliva. © 1979, Nature Publishing Group. All Rights Reserved.