CHRONIC TOXICITY OF STYRENE MALEIC-ANHYDRIDE, A MALE CONTRACEPTIVE, IN RHESUS-MONKEYS (MACACA-MULATTA)

被引：21

作者：

SETHI, N

SRIVASTAVA, RK

SINGH, RK

BHATIA, GS

SINHA, N

机构：

[1] Division of Toxicology Central Drug Research Institute Lucknow

来源：

CONTRACEPTION | 1990年 / 42卷 / 03期

关键词：

D O I：

10.1016/0010-7824(90)90021-M

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

A newly developed male contraceptive, styrene maleic anhydride (SMA), was injected in the vas deferens of male rhesus monkeys for safety evaluation at the dose of 100 mg (contraceptive dose, CD), 250 mg (CD × 2.5) and 500 mg (CD × 5.0), and the monkeys were kept under observation for one year. The observed behavioural, haematological, biochemical and histopathological parameters in treated monkeys were comparable to controls. The results suggest the polymer SMA to be safe up to 5 times CD in monkeys. © 1990.

引用

页码：337 / 347

页数：11

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[4]

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