ANTIHEPATOTOXIC EFFECTS OF CHLOROGENIC ACID FROM ANTHOCEPHALUS-CADAMBA

被引：70

作者：

KAPIL, A ^{[1
]}

KOUL, IB ^{[1
]}

SURI, OP ^{[1
]}

机构：

[1] REG RES LAB, DEPT CHEM, JAMMU 180001, INDIA

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 03期

关键词：

ANTHOCEPHALUS CADAMBA; CHLOROGENIC ACID; ANTIOXIDANT ACTIVITY; ANTIHEPATOTOXICITY; HEPATOPROTECTION;

D O I：

10.1002/ptr.2650090307

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present study, chlorogenic acid (CGA) isolated from Anthocephalus cadamba was screened for hepatoprotective activity by in vitro and in vivo assay methods using carbon tetrachloride (CCl4) as a model of liver injury. Intraperitoneal administration of CGA to mice at a dose of 100 mg/kg body weight for 8 days caused significant reversal in lipid peroxidation, enzymatic leakage, cytochrome P450 (Cyt P450) inactivation and produced enhancement of cellular antioxidant defence in CCl4-intoxicated mice, revealing that the antioxidative action of CGA is responsible for its liver protective activity. CGA exhibited a better therapeutic protective action than silymarin (SM), in CCl4-administered mice.

引用

页码：189 / 193

页数：5

共 29 条

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