ANALYSIS OF THE STIMULANT EFFECTS OF 5-HYDROXYTRYPTAMINE ON ISOLATED, BLOOD-PERFUSED RAT-HEART

被引：18

作者：

SAKAI, K

AKIMA, M

机构：

[1] Department of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co., Ltd., Toshima-ku, Tokyo

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 55卷 / 04期

关键词：

5-HT receptor; Cardiac and vascular responses; Coronary perfusion; Rat isolated heart;

D O I：

10.1016/0014-2999(79)90119-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In rat isolated hearts at a fixed flow rate, single injections of 5-hydroxytryptamine (5-HT) (0.1-3 μg) into the coronary perfusion produced dose-dependent increases in left ventricular (LV) dP/dt max and perfusion pressure (PP), but no clear changes in heart rate. The increases in the LVdP/dt max and PP were not significantly affected by treatment with propranolol, while they were abolished by methysergide. The present study indicates that the positive inotropic and vasoconstrictor of the rat heart to 5-HT are not mediated by endogenous catecholamine release, but are induced by a direct action on 5-HT receptors. © 1979.

引用

页码：421 / 424

页数：4

共 7 条

[1] PHARMACOLOGIC ANALYSIS OF CHRONOTROPIC AND INOTROPIC RESPONSES TO 5-HYDROXYTRYPTAMINE IN DOG HEART [J].