PENTAFLUOROPHENYLDIAZOALKANES AS NOVEL DERIVATIZATION REAGENTS FOR THE DETERMINATION OF SENSITIVE CARBOXYLIC-ACIDS BY GAS-CHROMATOGRAPHY NEGATIVE-ION MASS-SPECTROMETRY

被引：22

作者：

HOFMANN, U ^{[1
]}

HOLZER, S ^{[1
]}

MEESE, CO ^{[1
]}

机构：

[1] DR MARGARETE FISCHER BOSCH INST CLIN PHARMACOL,AUERBACHSTR 112,W-7000 STUTTGART 50,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 508卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(00)91277-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A convenient access to analytically useful pentafluorobenzyl esters of sensitive carboxylic acids is described. The novel derivatization procedure takes advantage of the chemoselectivity of diazo compounds towards acids and utilizes pentafluorophenyldiazoalkanes as derivatization reagents. The superiority of the diazo reagent over pentafluorobenzyl bromide is demonstrated with the efficient derivatization of sensitive carboxylic acids which decompose extensively when subjected to the routine procedure. The α-methylpentafluorobenzyl (MPFB) esters of mono- and dicarboxylic acids thus formed exhibit excellent gas chromatographic properties. The scope and limitation of the use of diastereomeric MPFB esters is also discussed. © 1990.

引用

页码：349 / 356

页数：8

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