CHARACTERISTICS OF WOODCHUCK HEPATITIS X-ANTIGEN IN THE LIVERS AND SERA FROM INFECTED ANIMALS

被引：22

作者：

FEITELSON, MA ^{[1
]}

LEGA, L ^{[1
]}

DUAN, LX ^{[1
]}

CLAYTON, M ^{[1
]}

机构：

[1] FOX CHASE CANC CTR, PHILADELPHIA, PA 19111 USA

来源：

JOURNAL OF HEPATOLOGY | 1993年 / 17卷

关键词：

WOODCHUCK HEPATITIS VIRUS; X-ANTIGEN; PATHOGENESIS;

D O I：

10.1016/S0168-8278(05)80420-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study tests the hypothesis that woodchuck hepatitis virus encoded X-antigen expression correlates with viral replication, with hepatitis, or with both. Paired liver and serum samples from each of 55 infected woodchucks were used. Seven of 8 carriers with high levels of viral DNA in serum also had X-antigen in serum. In contrast, the frequency of X-antigen in serum was low among infected woodchucks that did not have viral surface antigen in the serum. Statistical analysis showed a significant relationship between X-antigen in serum and markers of viral replication. Woodchuck hepatitis X-antigen (WHxAg) expression in liver but not serum of carriers closely correlated with the presence of hepatitis. The finding of X-antigen in the liver of infected animals with hepatitis that cleared the virus surface antigen from serum also suggests that X-antigen is associated with ongoing hepatitis. Hence, the persistence of WHxAg in serum may signal continuing viral replication and, in liver, may contribute to the pathogenesis of chronic infection.

引用

页码：S24 / S34

页数：11

共 38 条

[1] THE HEPATITIS-B VIRUS X-GENE PRODUCT TRANS-ACTIVATES BOTH RNA POLYMERASE-II AND III-PROMOTERS [J].