METABOLIC ENGINEERING FOR PRODUCTION OF BETA-CAROTENE AND LYCOPENE IN SACCHAROMYCES-CEREVISIAE

被引：106

作者：

YAMANO, S

ISHII, T

NAKAGAWA, M

IKENAGA, H

MISAWA, N

机构：

[1] KIRIN BREWERY CO LTD, CENT LABS KEY TECHNOL, KANAZAWA KU, YOKOHAMA, KANAGAWA 236, JAPAN

[2] KIRIN BREWERY CO LTD, NEW BIOBUSINESS RES CTR, TAKASAKI, GUMMA 37012, JAPAN

[3] KIRIN BREWERY CO LTD, PHARMACEUT LAB, TAKASAKI, GUMMA 37012, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 06期

关键词：

D O I：

10.1271/bbb.58.1112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have engineered a conventional yeast, Saccharomyes cerevisiae, to confer a novel biosynthetic pathway for the production of beta-carotene and lycopene by introducing the bacterial carotenoid biosynthesis genes, which are individually surrounded by the promoters and terminators derived from S. cerevisiae. beta-Carotene and lycopene accumulated in the cells of this yeast, which was considered to be a result of the carbon how for the ergosterol biosynthetic pathway being partially directed to the pathway for the carotenoid production.

引用

页码：1112 / 1114

页数：3

共 24 条

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