CDNA CLONING OF HUMAN KIDNEY PYRUVATE-CARBOXYLASE

被引：18

作者：

MACKAY, N

RIGAT, B

DOUGLAS, C

CHEN, HS

ROBINSON, BH

机构：

[1] UNIV TORONTO,DEPT BIOCHEM & PAEDIAT,TORONTO M5G 1X8,ON,CANADA

[2] HOSP SICK CHILDREN,RES INST,TORONTO M5G 1X8,ON,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

cDNA clones covering a total of 4017 bp were isolated corresponding to the full length of the message for human pyruvate carboxylase. The coding sequence consisted of a stretch of 3534 bp flanked by a 5' untranslated sequence of 82 bp and a 3' untranslated region of 389 bp excluding the poly-A tail. The translated amino acid sequence of 1178 residues contained consensus sequences for the covalent attachment for biotin, the binding of ATP and the binding of the substrate, pyruvate. (C) 1994 Academic Press, Inc.

引用

页码：1009 / 1014

页数：6

共 23 条

[1]

BROWNER MF, 1989, J BIOL CHEM, V264, P12680

[2]

COUDE FX, 1981, PEDIATRICS, V68, P914

[3] ACTIVITIES OF PYRUVATE CARBOXYLASE, PHOSPHOENOLPYRUVATE CARBOXYLASE AND FRUCTOSE DIPHOSPHATASE IN MUSCLES FROM VERTEBRATES AND INVERTEBRATES [J].

CRABTREE, B ;

NEWSHOLME, EA ;

HIGGINS, SJ .

BIOCHEMICAL JOURNAL, 1972, 130 (02) :391-+

[4]

Elgar G., 1992, DNA Sequence, V2, P219, DOI 10.3109/10425179209020806

[5]

Erlich H. A., 1989, PCR TECHNOLOGY PRINC

[6]

FREYTAG SO, 1984, J BIOL CHEM, V259, P2831

[7]

Genbauffe F S, 1991, DNA Seq, V2, P19, DOI 10.3109/10425179109008435

[8]

GOSS NH, 1984, METHOD ENZYMOL, V107, P261

[9] LACTIC-ACIDOSIS DUE TO PYRUVATE-CARBOXYLASE DEFICIENCY [J].

HAWORTH, JC ;

ROBINSON, BH ;

PERRY, TL .

JOURNAL OF INHERITED METABOLIC DISEASE, 1981, 4 (02) :57-58

[10]

KOZAK M, 1991, J BIOL CHEM, V266, P19867

← 1 2 3 →