DNA METHYLATION IN EUKARYOTES

被引：105

作者：

MARTIENSSEN, RA ^{[1
]}

RICHARDS, EJ ^{[1
]}

机构：

[1] WASHINGTON UNIV, DEPT BIOL, ST LOUIS, MO 63130 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 02期

关键词：

D O I：

10.1016/0959-437X(95)80014-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advances have expanded our understanding of the processes underlying the establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes. The functional significance of DNA methylation is sought in a comparison of results on a variety of epigenetic phenomena in different eukaryotes. The recent development of DNA methylation mutants in mice, Neurospora, and Arabadopsis will allow traditional genetic dissection to be applied to long-standing problems regarding the function and regulation of eukaryotic DNA methylation. Although methylation appears to be important for maintenance of different epigenetic states, the mechanism that establishes these states is likely to involve additional processes.

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页码：234 / 242

页数：9

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