INCREASED SYSTEMIC BIOAVAILABILITY OF ALBENDAZOL WHEN ADMINISTERED WITH SURFACTANTS IN RATS

被引：14

作者：

DELESTAL, JL ^{[1
]}

ALVAREZ, AI ^{[1
]}

VILLAVERDE, C ^{[1
]}

JUSTEL, A ^{[1
]}

PRIETO, JG ^{[1
]}

机构：

[1] UNIV LEON,DEPT PHYSIOL PHARMACOL & TOXICOL,E-24071 LEON,SPAIN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 102卷 / 1-3期

关键词：

ALBENDAZOL; BIOAVAILABILITY; SURFACTANT; RAT;

D O I：

10.1016/0378-5173(94)90063-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This work describes the determination of the plasma concentrations of albendazol sulfoxide (ABZ.SO) after administration of single oral doses of albendazol (ABZ) using surfactants as vehicles (Tween 80 and sodium taurocholate). The pharmacokinetic parameters AUC, C-max and t(max) were affected by the use of surfactants. The results showed higher plasma levels of ABZ.SO and the ratio, AUC/initial dose, was 60-100-times greater in the presence of surfactants.

引用

页码：257 / 260

页数：4

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