PROBABLE METABOLIC INTERACTION BETWEEN METHADONE AND FLUVOXAMINE IN ADDICT PATIENTS

被引：63

作者：

BERTSCHY, G

BAUMANN, P

EAP, CB

BAETTIG, D

机构：

[1] Département Universitaire de Psychiatrie Adulte, Lausanne

来源：

THERAPEUTIC DRUG MONITORING | 1994年 / 16卷 / 01期

关键词：

ADDICT PATIENTS; DEPRESSION; FLUVOXAMINE; METHADONE; PHARMACOKINETIC INTERACTION;

D O I：

10.1097/00007691-199402000-00006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We report five cases where fluvoxamine (FLVX) was added to maintenance treatment with methadone (MTD) in addict patients with affective disorders. In view of the implication of FLVX in several metabolic drug interactions, MTD plasma levels were measured before and after treatment with FLVX. A slight increase (similar to 20% of the MTD plasma level/dose ratio) occurred in two cases. In the remaining three patients, the interaction was more pronounced (40-100% increase of the MTD plasma level/dose ratio), with clinical manifestations of opiate withdrawal after stopping FLVX therapy in one case. Caution is needed when starting or stopping treatment with FLVX in patients receiving maintenance treatment with methadone.

引用

页码：42 / 45

页数：4

共 28 条

[1] CLINICAL PHARMACOKINETICS OF CITALOPRAM AND OTHER SELECTIVE SEROTONERGIC REUPTAKE INHIBITORS (SSRI) [J].