THE 3'-UNTRANSLATED REGIONS FROM THE TRYPANOSOMA-BRUCEI PHOSPHOGLYCERATE KINASE-ENCODING GENES MEDIATE DEVELOPMENTAL REGULATION

被引：49

作者：

BLATTNER, J ^{[1
]}

CLAYTON, CE ^{[1
]}

机构：

[1] UNIV HEIDELBERG,ZENTRUM MOLEK BIOL,D-69120 HEIDELBERG,GERMANY

来源：

GENE | 1995年 / 162卷 / 01期

关键词：

POSTTRANSCRIPTIONAL REGULATION; KINETOPLASTIDAE; GLYCOLYSIS; TRANSFECTION; POLYADENYLATION;

D O I：

10.1016/0378-1119(95)00366-E

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The phosphoglycerate kinase (PGK)-encoding genes of Trypanosoma brucei are transcribed in a polycistronic fashion, but the mRNAs encoding the three PGK isozymes show differing developmental regulation. We demonstrate here that the 3'-untranslated regions of the major cytoplasmic and glycosomal PGK isozymes are capable of conferring the anticipated types of regulation on a transfected reporter gene.

引用

页码：153 / 156

页数：4

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