ISOLATED FOLLICLE-STIMULATING-HORMONE DEFICIENCY REVISITED - OVULATION AND CONCEPTION IN PRESENCE OF CIRCULATING ANTIBODY TO FOLLICLE-STIMULATING-HORMONE

WE have previously described the clinical features of a 22-year-old woman who was evaluated in 1971 for primary amenorrhea and in whom we established the diagnosis of isolated deficiency of follicle-stimulating hormone (FSH).1,2 Serum FSH levels were undetectable, whereas luteinizing hormone (LH) levels were in the postmenopausal range (50 to 90 mIU per milliliter). She had received two courses of therapy with human menopausal gonadotropins (menotropins), after which we detected human anti-FSH antibody in her serum. We now report the successful induction of ovulation and conception, with subsequent uneventful pregnancy, in this unique patient with isolated FSH deficiency and anti-FSH. © 1979, Massachusetts Medical Society. All rights reserved.