INFLUENCE OF MIXING TIME AND COLLOIDAL SILICA ON THE LUBRICATING PROPERTIES OF MAGNESIUM STEARATE

被引：52

作者：

RAGNARSSON, G

HOLZER, AW

SJOGREN, J

机构：

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1979年 / 3卷 / 2-3期

关键词：

D O I：

10.1016/0378-5173(79)90074-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of mixing time and colloidal silica on the lubricating properties of magnesium stearate was studied using an instrumented single-punch machine. The lubricant was mixed with sodium chloride, anhydrous lactose, calcium citrate granulate and sodium chloride-colloidal silica-mixtures. Short mixing time decreased the negative effects of magnesium stearate on tablet strength and disintegration without reducing the lubricating efficiency. Addition of colloidal silica had a positive effect on the strength of lubricated sodium chloride tablets but increased the friction and did not improve the disintegration. © 1979.

引用

页码：127 / 131

页数：5

共 11 条

[1]

Bolhuis G.K., 1975, PHARM WEEKBL SCI, V110, P317

[2] BONDING CHARACTERISTICS BY SCANNING ELECTRON-MICROSCOPY OF POWDERS MIXED WITH MAGNESIUM STEARATE [J].