INCORPORATION OF INOSITOL INTO THE PHOSPHOINOSITIDES OF LYMPHOBLASTOID CELL-LINES ESTABLISHED FROM BIPOLAR MANIC-DEPRESSIVE PATIENTS

被引：17

作者：

BANKS, RE

AITON, JF

CRAMB, G

NAYLOR, GJ

机构：

[1] UNIV ST ANDREWS,DEPT BIOL & PRECLIN MED,BUTE MED BLDG,ST ANDREWS KY16 9TS,FIFE,SCOTLAND

[2] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT PSYCHIAT,DUNDEE DD1 9SY,SCOTLAND

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1990年 / 19卷 / 01期

基金：

英国惠康基金;

关键词：

Lymphoblastoid cells; Manic-depressive psychosis; Polyphosphoinositides;

D O I：

10.1016/0165-0327(90)90002-P

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lymphoblastoid cell lines established from patients suffering from bipolar manic-depressive psychosis or from a control group have been used to study the metabolism of the polyphosphoinositides in these cells. Cells were incubated for up to 6 h in [3H]inositol and the extent of inositol incorporation into the mono-, di- and triphosphoinositides was measured after extracting the water- and lipid-soluble inositol-containing pools. Although both the uptake of inositol and the 'free' intracellular inositol pool sizes were similar in the two cell groups, the incorporation of [3H]inositol into the phosphoinositides of the cells derived from bipolar manic-depressives was significantly less (by around 50-60%) than that which occurred in the control cells. © 1990.

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页码：1 / 8

页数：8

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