ASYMMETRIC DIELS-ALDER REACTIONS WITH GAMMA-FUNCTIONALIZED ALPHA,BETA-UNSATURATED CHIRAL N-ACYLOXAZOLIDINONES - SYNTHESIS OF (+)-S-145

被引：49

作者：

MARTINELLI, MJ

机构：

[1] Process Research & Development Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 17期

关键词：

D O I：

10.1021/jo00304a019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An extension of the asymmetric Diels-Alder cycloaddition with chiral γ-substituted, α,β-unsaturated imides is described. The application of these results to the synthesis of the potent TxA2 receptor antagonist (+)-S-145 was successfully achieved in a practical manner. © 1990, American Chemical Society. All rights reserved.

引用

页码：5065 / 5073

页数：9

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