SYNTHESIS OF 5-CYCLOPROPYLURACIL AND 5-CYCLOPROPYLCYTOSINE BY THE PD(0)-CATALYZED COUPLING REACTION

被引：21

作者：

PETERS, D

HORNFELDT, AB

GRONOWITZ, S

机构：

[1] Chemical Center, Lund, S-22100, Organic Chemistry 1

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 06期

关键词：

D O I：

10.1002/jhet.5570280629

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Cyclopropyluracil and cyclopropylcytosine were prepared by the Pd(0)-catalyzed coupling reaction of 5-bromo-2,4-di(trimethylsilyloxy)pyrimidine and 5-bromo-2,4-O,N-bis-trimethylsilylcytosine with tributylstannylcyclopropane. The reactions also gave dehalogenated pyrimidine bases as by-products. Attempts to use 2,4-O,N-bis-trimethylsilyl-5-iodocytosine as the halide gave complete dehalogenation.

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页码：1629 / 1631

页数：3

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