THE CHROMOSOMES OF LEISHMANIA

被引：38

作者：

LIGHTHALL, GK ^{[1
]}

GIANNINI, SH ^{[1
]}

机构：

[1] UNIV MARYLAND, SCH MED, DEPT MICROBIOL & IMMUNOL, BALTIMORE, MD 21201 USA

来源：

PARASITOLOGY TODAY | 1992年 / 8卷 / 06期

关键词：

D O I：

10.1016/0169-4758(92)90263-2

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Chromosome size polymorphisms occur in Leishmania such that each strain of a given species has a distinctive molecular karyotype. Despite this variability, the chromosomal similarities among closely related strains of Leishmania are sufficiently characteristic to permit classification of unidentified clinical isolates. Mechanisms generating chromosome size polymorphisms are related to chromosomal evolution. In this review, Geoffrey Lighthall and Suzanne Giannini explain that the chromosomal profiles of members of different species may be diverging from a conserved 'consensus' karyotype at different rates, and present a current understanding of the genomic organization of Leishmania with emphasis on chromosomal elements.

引用

页码：192 / 199

页数：8

共 55 条

[1] MULTIPLE COPIES OF A RETROPOSON INTERRUPT SPLICED LEADER RNA GENES IN THE AFRICAN TRYPANOSOME, TRYPANOSOMA-GAMBIENSE [J].

AKSOY, S ;

LALOR, TM ;

MARTIN, J ;

VANDERPLOEG, LHT ;

RICHARDS, FF .

EMBO JOURNAL, 1987, 6 (12) :3819-3826

[2] GENETIC-CHARACTERIZATION OF LEISHMANIA ISOLATES AT 37 ENZYME LOCI [J].

ANDREWS, RH ;

HANDMAN, E ;

ADAMS, M ;

BAVERSTOCK, PR ;

MITCHELL, GF .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1988, 18 (04) :445-452

[3]

Ashford R.W., 1987, P365

[4]

BARD E, 1990, FED AM SOC EXP BIOL, V4, pA1824

[5] GENE AMPLIFICATION IN LEISHMANIA [J].

BEVERLEY, SM .

ANNUAL REVIEW OF MICROBIOLOGY, 1991, 45 :417-444

[6] PRIMARY STRUCTURE OF THE GENE ENCODING THE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF LEISHMANIA-MAJOR [J].

BEVERLEY, SM ;

ELLENBERGER, TE ;

CORDINGLEY, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (08) :2584-2588

[7] EVOLUTION OF THE GENUS LEISHMANIA AS REVEALED BY COMPARISONS OF NUCLEAR-DNA RESTRICTION FRAGMENT PATTERNS [J].

BEVERLEY, SM ;

ISMACH, RB ;

PRATT, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (02) :484-488

[8] RECURRENT DENOVO APPEARANCE OF SMALL LINEAR DNAS IN LEISHMANIA-MAJOR AND RELATIONSHIP TO EXTRACHROMOSOMAL DNAS IN OTHER SPECIES [J].

BEVERLEY, SM ;

COBURN, CM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1990, 42 (01) :133-141

[9] CHROMOSOME SIZE POLYMORPHISMS OF LEISHMANIA-DONOVANI [J].

BISHOP, RP ;

MILES, MA .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 24 (03) :263-272

[10] IDENTIFICATION OF A TELOMERIC DNA-SEQUENCE IN TRYPANOSOMA-BRUCEI [J].

BLACKBURN, EH ;

CHALLONER, PB .

CELL, 1984, 36 (02) :447-457

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