ALLOGENEIC BONE-MARROW TRANSPLANTATION AS THERAPY FOR PRIMARY INDUCTION FAILURE FOR PATIENTS WITH ACUTE-LEUKEMIA

被引:68
作者
FORMAN, SJ
SCHMIDT, GM
NADEMANEE, AP
AMYLON, MD
CHAO, NJ
FAHEY, JL
KONRAD, PN
MARGOLIN, KA
NILAND, JC
ODONNELL, MR
PARKER, PM
SMITH, EP
SNYDER, DS
SOMLO, G
STEIN, AS
BLUME, KG
机构
[1] CITY HOPE NATL MED CTR, DEPT BIOSTAT, DUARTE, CA 91010 USA
[2] STANFORD UNIV, DEPT MED, BONE MARROW TRANSPLANT PROGRAM, STANFORD, CA 94305 USA
关键词
D O I
10.1200/JCO.1991.9.9.1570
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The survival of patients with acute leukemia who do not achieve a remission with primary therapy is very poor. High-dose chemoradiotherapy followed by allogeneic bone marrow transplantation (BMT) has been shown to be effective therapy for patients with acute and chronic leukemia. Therefore, we determined the long-term disease-free survival of patients who did not achieve a remission and were then treated with high-dose therapy and bone marrow allografting from matched sibling donors. Twenty-one patients (median age, 28 years) who did not achieve a remission with induction chemotherapy were subsequently treated with allogeneic BMT. After BMT, 90% achieved a complete remission. Six died of complications of the therapy, and six patients relapsed between 27 and 448 days after BMT. Nine patients (43%; median age, 25 years) are alive between 556 and 4,174 days after BMT. The cumulative probability of disease-free survival at 10 years is 43%. This study suggests that allogeneic BMT can be an effective therapy to achieve long-term control of acute leukemia, even in those patients who do not achieve a remission with primary therapy. © 1991 by American Society of Clinical Oncology.
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收藏
页码:1570 / 1574
页数:5
相关论文
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