NUCLEOCYCLITOLS - SYNTHESIS OF SUBSTITUTED PURINYL-MUCO-INOSITOL DERIVATIVES

被引：8

作者：

AGUILAR, GJ

GELPI, ME

CADENAS, RA

机构：

[1] Departamento de Química, Facultad de Agronomía, Universidad de Buenos Aires, Buenos Aires, 4453

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 02期

关键词：

D O I：

10.1002/jhet.5570290219

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several carbocyclic nucleoside analogs possessing a 6-substituted purine linked to a mesylated muco-ino-sitol were synthesized. The coupling of triethylamine-activated 6-chloropurine with 2,3-anhydro-1,5,6-tri-0-(methanesulfonyl)-epi-inositol gave a 6-chloro purinyl muco-inositol amenable to further synthetic transformations in the heterocyclic moiety by substitution of the chlorine atom by nitrogen nucleophiles such as methylamino, diethylamino, benzylamino, hydrazino, morpholino, hydroxylamino, piperidino, and glycyl groups.

引用

收藏

页码：401 / 405

页数：5

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