THE STRUCTURE OF THE PRODUCTS WHEN ALPHA-BROMOACETOARENONES REACT WITH 3-(N,N-DIMETHYLAMINO)PROPAN-1-OL

被引：3

作者：

GARCIA, JG ^{[1
]}

FRONCZEK, FR ^{[1
]}

GANDOUR, RD ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,DEPT CHEM,BATON ROUGE,LA 70803

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80441-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-(N,N-Dimethylamino)propan-1-ol readily reacts at room temperature with aryl alpha-bromoacetophenones to form N-(3-hydroxypropyl)-N,N-dimethyl-N-[2-oxo-2-arylethyl]ammonium bromides in yields up to 89%. Contrary to a previous report (J. Med. Chem. 1966, 9, 211-213), the seven-membered ring hemiketal is not formed. An X-ray structure of the 4-phenylphenyl compound shows the open form.

引用

页码：157 / 160

页数：4

共 14 条

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