CHARACTERIZATION OF URSOLIC ACID AS A LIPOXYGENASE AND CYCLOOXYGENASE INHIBITOR USING MACROPHAGES, PLATELETS AND DIFFERENTIATED HL-60 LEUKEMIC-CELLS

被引：105

作者：

NAJID, A

SIMON, A

COOK, J

CHABLERABINOVITCH, H

DELAGE, C

CHULIA, AJ

RIGAUD, M

机构：

[1] UNIV LIMOGES,FAC PHARM,PHARMACOGNOSIE LAB,F-87025 LIMOGES,FRANCE

[2] UNIV LIMOGES,FAC PHARM,CHIM PHYS LAB,F-87025 LIMOGES,FRANCE

来源：

FEBS LETTERS | 1992年 / 299卷 / 03期

关键词：

LIPOXYGENASE; ARACHIDONIC ACID; CYCLOOXYGENASE; URSOLIC ACID; CALLUNA-VULGARIS;

D O I：

10.1016/0014-5793(92)80117-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) which could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1-mu-M, blocks arachidonate metabolism.

引用

页码：213 / 217

页数：5

共 13 条

[1] ARACHIDONIC-ACID METABOLISM IN POLYMORPHONUCLEAR LEUKOCYTES .3. EFFECTS OF IONOPHORE-A23187 [J].