A FORMAL TOTAL SYNTHESIS OF NIKKOMYCIN-B BASED ON ENZYMATIC RESOLUTION OF A PRIMARY ALCOHOL POSSESSING 2 STEREOGENIC CENTERS

被引：18

作者：

AKITA, H

CHEN, CY

UCHIDA, K

机构：

[1] School of Pharmaceutical Science, Toho University, Funabashi, Chiba, 274, 2-2-1, Miyama

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 09期

关键词：

D O I：

10.1016/0957-4166(95)00282-T

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A highly stereoselective synthesis of the versatile chiral synthon possessing two stereogenic centers, (2S,3S)-8 (>99% ee) was achieved and the conversion of (2S,3S)-8 into the homochiral intermediate (2S,3S,4S)-1 for the synthesis of nikkomycin B is described.

引用

页码：2131 / 2134

页数：4

共 5 条

[1] A HIGHLY STEREOSELECTIVE SYNTHESIS OF THE VERSATILE CHIRAL SYNTHONS POSSESSING 2 STEREOGENIC CENTERS, THE FORMAL TOTAL SYNTHESES OF (-)-OUDEMANSIN-A, (-)-OUDEMANSIN-B, AND (-)-OUDEMANSIN-X [J].