MICROSATELLITE EVOLUTION - EVIDENCE FOR DIRECTIONALITY AND VARIATION IN RATE BETWEEN SPECIES

被引：262

作者：

RUBINSZTEIN, DC

AMOS, W

LEGGO, J

GOODBURN, S

JAIN, S

LI, SH

MARGOLIS, RL

ROSS, CA

FERGUSONSMITH, MA

机构：

[1] UNIV CAMBRIDGE,DEPT GENET,CAMBRIDGE CB2 2QQ,ENGLAND

[2] ADDENBROOKES HOSP,DEPT CLIN GENET,CAMBRIDGE CB2 2QQ,ENGLAND

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,MOLEC NEUROBIOL LAB,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

[5] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND

来源：

NATURE GENETICS | 1995年 / 10卷 / 03期

关键词：

D O I：

10.1038/ng0795-337

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Microsatellite DNA sequences are rapidly becoming the dominant source of nuclear genetic markers for a wide range of applications, from genome mapping to forensic testing to population studies. If misinterpretation is to be avoided, it is vital that we understand fully the way in which microsatellite sequences evolve. We have therefore compared allele length distributions for 42 microsatellites in humans with their homologues in a range of related primates. We find a highly significant trend for the loci to be longer in humans, showing that microsatellites can evolve directionally and at different rates in closely related species.

引用

页码：337 / 343

页数：7

共 46 条

[1] THE RELATIONSHIP BETWEEN TRINUCLEOTIDE (CAG) REPEAT LENGTH AND CLINICAL-FEATURES OF HUNTINGTONS-DISEASE [J].