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LOCALIZATION OF A HUMAN NA+, K+-ATPASE ALPHA-SUBUNIT GENE TO CHROMOSOME-19Q12-]Q13.2 AND LINKAGE TO THE MYOTONIC-DYSTROPHY LOCUS
被引：32
作者：
HARLEY, HG
BROOK, JD
JACKSON, CL
GLASER, T
WALSH, KV
SARFARAZI, M
KENT, R
LAGER, M
KOCH, M
HARPER, PS
LEVENSON, R
HOUSMAN, DE
SHAW, DJ
机构：
来源：
关键词：
D O I：
10.1016/0888-7543(88)90131-0
中图分类号：
Q81 [生物工程学（生物技术）];
Q93 [微生物学];
学科分类号：
071005 ;
0836 ;
090102 ;
100705 ;
摘要：
The gene coding for a Na+,K+-ATPase .alpha. subunit (ATP1A3) has been localized to the q12.fwdarw.q13.2 region of human chromosome 19, potentially close to the myotonic dystrophy (DM) gene. In view of previous studies implicating a Na+,K+-ATPase in the pathology of DM, we have examined the possibility that ATP1A3 is a candidate for the DM locus. Although linked, several clear instances of recombination between ATP1A3 and DM rule out the possibility that mutations in ATP1A3 cause the disease. Examination of multiply informative pedigrees indicates the gene order DM-AP0C2-ATP1A3.
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页码：380 / 384
页数：5
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