STIMULATION OF GASTRIN-SECRETION FROM THE PERFUSED RAT STOMACH BY SOMATOSTATIN ANTISERUM

被引：139

作者：

SAFFOURI, B

WEIR, G

BITAR, K

MAKHLOUF, G

机构：

[1] MED COLL VIRGINIA,DIV GASTROENTEROL,RICHMOND,VA 23298

[2] MED COLL VIRGINIA,DIV ENDOCRINOL,RICHMOND,VA 23298

来源：

LIFE SCIENCES | 1979年 / 25卷 / 20期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0024-3205(79)90478-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of a high capacity somatostatin antiserum on antral gastrin secretion was examined in an isolated vascularly perfused rat stomach preparation. Infusion of somatostatin antiserum diluted 1:1 and 1:9 with Krebs buffer solution produced significant increases in gastrin secretion throughout the period of infusion. Neither infusion of somatostatin antiserum diluted 1:99 nor infusion of control rabbit serum had any effect on gastrin secretion. The data indicate that antral somatostatin excercises a continous restraint on gastrin secretion in the basal state. © 1979.

引用

页码：1749 / 1753

页数：5

共 11 条

[1] PENTAGASTRIN AND ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE STIMULATED SECRETION OF SOMATOSTATIN FROM PERIFUSED RAT GASTRIC-MUCOSA
BARDEN, N
DUPONT, A
COTE, JP
[J]. LIFE SCIENCES, 1979, 24 (08) : 739 - 742
[2] GASTRIN RELEASE BY BOMBESIN IN DOG
BERTACCINI, G
ERSPAMER, V
MELCHIORRI, P
SOPRANZI, N
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1974, 52 (02) : 219 - 225
[3] PARTICIPATION OF ANTRAL SOMATOSTATIN IN LOCAL REGULATION OF GASTRIN RELEASE
GUSTAVSSON, S
LUNDQVIST, G
[J]. ACTA ENDOCRINOLOGICA, 1978, 88 (02): : 339 - 346
[4] INHIBITION OF GASTRIN RELEASE BY SOMATOSTATIN INVITRO
HAYES, JR
JOHNSON, DG
KOERKER, D
WILLIAMS, RH
[J]. ENDOCRINOLOGY, 1975, 96 (06) : 1374 - 1376
[5] HELMSTAEDTER V, 1977, CELL TISSUE RES, V177, P29
[6] IMMUNOHISTOCHEMICAL LOCALIZATION OF SOMATOSTATIN IN ENDOCRINE CELLS OF RAT STOMACH
LECLERC, R
PELLETIER, G
PUVIANI, R
ARIMURA, A
SCHALLY, AV
[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1976, 4 (04) : 257 - 261
[7] POLAK JM, 1975, LANCET, V1, P1220
[8] SAFFOURI B, 1979, GASTROENTEROLOGY, V76, P1233
[9] SCHEBALIN M, 1977, GASTROENTEROLOGY, V73, P79
[10] PANCREATIC AND GASTRIC SOMATOSTATIN RELEASE IN RESPONSE TO INTRA-GASTRIC AND INTRA-DUODENAL NUTRIENTS AND HCL IN DOG
SCHUSDZIARRA, V
HARRIS, V
CONLON, JM
ARIMURA, A
UNGER, R
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (03) : 509 - 518

← 1 2 →