THE USE OF PEARLMAN CATALYST FOR SELECTIVE N-DEBENZYLATION IN THE PRESENCE OF BENZYL ETHERS

被引：67

作者：

BERNOTAS, RC

CUBE, RV

机构：

[1] Merrell Dow Research Institute, 2110 E. Galbraith Rd. Cincinnati, Ohio

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 08期

关键词：

D O I：

10.1080/00397919008052829

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrogenation with 20% palladium hydroxide on carbon selectively removes benzyl groups from amines in high yields without cleaving benzyl ethers. Copyright © 1990 by Taylor & Francis Group. All rights reserved.

引用

页码：1209 / 1212

页数：4

共 11 条

[1]

ADGER BM, 1987, SYNTHESIS-STUTTGART, P53

[2]

HANESSIAN S, 1981, SYNTHESIS-STUTTGART, P396

[3]

HARTUNG WH, 1953, ORG REACTIONS, V7, P263

[4] ASYMMETRIC-SYNTHESIS OF TRANS-(2R,5R)-BIS(BENZYLOXYMETHYL)PYRROLIDINE [J].

MARZI, M ;

MISITI, D .

TETRAHEDRON LETTERS, 1989, 30 (44) :6075-6076

[5] A NEW REAGENT FOR THE SELECTIVE, HIGH-YIELD N-DEALKYLATION OF TERTIARY-AMINES - IMPROVED SYNTHESES OF NALTREXONE AND NALBUPHINE [J].

OLOFSON, RA ;

MARTZ, JT ;

SENET, JP ;

PITEAU, M ;

MALFROOT, T .

JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (11) :2081-2082

[6]

PEARLMAN WM, 1967, TETRAHEDRON LETT, P1663

[7] RAPID DEBENZYLATION OF N-BENZYLAMINO DERIVATIVES TO AMINO-DERIVATIVES USING AMMONIUM FORMATE AS CATALYTIC HYDROGEN TRANSFER AGENT [J].

RAM, S ;

SPICER, LD .

TETRAHEDRON LETTERS, 1987, 28 (05) :515-516

[8] DEBENZYLATION OF N-BENZYLAMINO DERIVATIVES BY CATALYTIC TRANSFER HYDROGENATION WITH AMMONIUM FORMATE [J].

RAM, S ;

SPICER, LD .

SYNTHETIC COMMUNICATIONS, 1987, 17 (04) :415-418

[9]

Rylander P., 1979, CATALYTIC HYDROGENAT, P274

[10] DIE KATALYTISCHE HYDRIERUNG VON ACETOPHENON MIT PLATIN UND PALLADIUM - EIN BEITRAG ZUR SELEKTIVITAT DER EDELMETALLKATALYSATOREN [J].

THEILACKER, W ;

DROSSLER, HG .

CHEMISCHE BERICHTE-RECUEIL, 1954, 87 (11) :1676-1684

← 1 2 →