INTERACTION OF DNA WITH A PORPHYRIN LIGAND - EVIDENCE FOR INTERCALATION

被引：380

作者：

FIEL, RJ ^{[1
]}

HOWARD, JC ^{[1
]}

MARK, EH ^{[1
]}

DATTAGUPTA, N ^{[1
]}

机构：

[1] S CAROLINA STATE COLL,ORANGEBURG,SC 29115

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 6卷 / 09期

关键词：

D O I：

10.1093/nar/6.9.3093

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The porphyrin photosensitizer, meso-Tetra(4-N-methyl-pyridyl)porphine tetraperchlorate binds to calf thymus DNA by intercalation and by external electrostatic association. This was concluded from the results of measurements involving Scatchard analysis, viscometry, thermal denaturation, and circular dichroism. © 1979 Information Retrieval Limited.

引用

收藏

页码：3093 / 3118

页数：26

相关论文

共 21 条

[1] NA-23 NMR-STUDIES OF CATION DNA INTERACTIONS [J].

ANDERSON, CF ;

RECORD, MT ;

HART, PA .

BIOPHYSICAL CHEMISTRY, 1978, 7 (04) :301-316

[2] COMPARATIVE BINDING STUDY OF INTERACTION OF QUINACRINE AND ETHIDIUM-BROMIDE WITH DNA AND NUCLEOHISTONE [J].

BONTEMPS, J ;

FREDERICQ, E .

BIOPHYSICAL CHEMISTRY, 1974, 2 (01) :1-22

[3]

BUNGELER W., 1937, ZEITSCHR KREBSFORSCH, V46, P130, DOI 10.1007/BF01634335

[4] VISCOSITY AND SEDIMENTATION STUDY OF SONICATED DNA-PROFLAVINE COMPLEXES [J].

COHEN, G ;

EISENBERG, H .

BIOPOLYMERS, 1969, 8 (01) :45-+

[5] SOME METAL-COMPLEXES OF ALPHA, BETA, GAMMA, DELTA-TETRA-(4-PYRIDYL) PORPHINE [J].

DATTAGUPTA, N ;

FANNING, JC ;

DICKENS, LL .

JOURNAL OF COORDINATION CHEMISTRY, 1976, 5 (04) :201-207

[6] PHOTORADIATION THERAPY .2. CURE OF ANIMAL TUMORS WITH HEMATOPORPHYRIN AND LIGHT [J].

DOUGHERTY, TJ ;

GRINDEY, GB ;

FIEL, R ;

WEISHAUPT, KR ;

BOYLE, DG .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1975, 55 (01) :115-121

[7]

FIEL RJ, 1975, RES COMMUN CHEM PATH, V10, P65

[8]

FIEL RJ, UNPUBLISHED

[9] STUDIES ON METHYL GREEN DNA COMPLEX AND ITS DISSOCIATION BY DRUGS [J].

KREY, AK ;

HAHN, FE .

BIOCHEMISTRY, 1975, 14 (23) :5061-5067

[10] ACRIDINE MUTAGENS + DNA STRUCTURE [J].

LERMAN, LS .

JOURNAL OF CELLULAR AND COMPARATIVE PHYSIOLOGY, 1964, 64 (2S12) :1-&