MEASLES-VIRUS NUCLEOCAPSID PROTEIN PROTECTS RATS FROM ENCEPHALITIS

被引：64

作者：

BANKAMP, B ^{[1
]}

BRINCKMANN, UG ^{[1
]}

REICH, A ^{[1
]}

NIEWIESK, S ^{[1
]}

TERMEULEN, V ^{[1
]}

LIEBERT, UG ^{[1
]}

机构：

[1] UNIV WURZBURG,INST VIROL & IMMUNBIOL,VERSBACHER STR 7,W-8700 WURZBURG,GERMANY

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 04期

关键词：

D O I：

10.1128/JVI.65.4.1695-1700.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lewis rats immunized with recombinant vaccinia virus expressing the nucleocapsid (N) protein of measles virus were protected from encephalitis when subsequently challenged by intracerebral infection with neurotropic measles virus. Immunized rats revealed polyvalent antibodies of the N protein of measles virus in the absence of any neutralizing antibodies as well as an N protein-specific proliferative lymphocyte response. Depletion of CD8+ T lymphocytes did not abrogate the protective potential of the N protein-specific cell-mediated immune response in rats, while protection could be adoptively transfered with N protein-specific CD4+ T lymphocytes. These results indicate that a CD4+ cell-mediated immune response specific for the N protein of measles virus is sufficient to control measles virus infections of the central nervous system.

引用

页码：1695 / 1700

页数：6

共 28 条

[1]

BILLETER MA, 1989, GENETICS AND PATHOGENICITY OF NEGATIVE STRAND VIRUSES, P356

[2] AN ADENOVIRUS TYPE-2 GLYCOPROTEIN BLOCKS CELL-SURFACE EXPRESSION OF HUMAN HISTOCOMPATIBILITY CLASS-I ANTIGENS [J].

BURGERT, HG ;

KVIST, S .

CELL, 1985, 41 (03) :987-997

[3] MUTATED AND HYPERMUTATED GENES OF PERSISTENT MEASLES VIRUSES WHICH CAUSED LETHAL HUMAN-BRAIN DISEASES [J].

CATTANEO, R ;

SCHMID, A ;

SPIELHOFER, P ;

KAELIN, K ;

BACZKO, K ;

TERMEULEN, V ;

PARDOWITZ, J ;

FLANAGAN, S ;

RIMA, BK ;

UDEM, SA ;

BILLETER, MA .

VIROLOGY, 1989, 173 (02) :415-425

[4] MULTIPLE VIRAL MUTATIONS RATHER THAN HOST FACTORS CAUSE DEFECTIVE MEASLES-VIRUS GENE-EXPRESSION IN A SUBACUTE SCLEROSING PANENCEPHALITIS CELL-LINE [J].

CATTANEO, R ;

SCHMID, A ;

BILLETER, MA ;

SHEPPARD, RD ;

UDEM, SA .

JOURNAL OF VIROLOGY, 1988, 62 (04) :1388-1397

[5] THE REGULATION AND EXPRESSION OF MHC CLASS-I GENES [J].

DAVID-WATINE, B ;

ISRAEL, A ;

KOURILSKY, P .

IMMUNOLOGY TODAY, 1990, 11 (08) :286-292

[6] PRESENTATION OF CMV IMMEDIATE-EARLY ANTIGEN TO CYTOLYTIC LYMPHOCYTE-T IS SELECTIVELY PREVENTED BY VIRAL GENES EXPRESSED IN THE EARLY PHASE [J].

DELVAL, M ;

MUNCH, K ;

REDDEHASE, MJ ;

KOSZINOWSKI, UH .

CELL, 1989, 58 (02) :305-315

[7] PROTECTION OF MICE FROM FATAL MEASLES ENCEPHALITIS BY VACCINATION WITH VACCINIA VIRUS RECOMBINANTS ENCODING EITHER THE HEMAGGLUTININ OR THE FUSION PROTEIN [J].

DRILLIEN, R ;

SPEHNER, D ;

KIRN, A ;

GIRAUDON, P ;

BUCKLAND, R ;

WILD, F ;

LECOCQ, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1252-1256

[8] IDENTIFICATION OF VIRAL MOLECULES RECOGNIZED BY INFLUENZA-SPECIFIC HUMAN CYTOTOXIC LYMPHOCYTES-T [J].

GOTCH, F ;

MCMICHAEL, A ;

SMITH, G ;

MOSS, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (02) :408-416

[9] ANTI-VIRAL PROTECTION AND PREVENTION OF LYMPHOCYTIC CHORIOMENINGITIS OR OF THE LOCAL FOOTPAD SWELLING REACTION IN MICE BY IMMUNIZATION WITH VACCINIA-RECOMBINANT VIRUS EXPRESSING LCMV-WE NUCLEOPROTEIN OR GLYCOPROTEIN [J].

HANY, M ;

OEHEN, S ;

SCHULZ, M ;

HENGARTNER, H ;

MACKETT, M ;

BISHOP, DHL ;

OVERTON, H ;

ZINKERNAGEL, RM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (03) :417-424

[10]

HERBERT J, 1988, TRANSPLANTATION S2, V46, P128

← 1 2 3 →