DOPAMINE AND THE ENHANCED RENAL RESPONSE TO ALDOSTERONE IN THE RAT ON A HIGH POTASSIUM DIET

被引：8

作者：

ADAM, WR

GOLAND, G

机构：

[1] Renal Unit, Repatriation General Hospital, Heidelberg, Victoria

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1979年 / 6卷 / 06期

关键词：

aldosterone; aldosterone response; catecholamine; dopamine; potassium;

D O I：

10.1111/j.1440-1681.1979.tb00047.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The enhanced renal response to aldosterone observed in rats on a high potassium diet is reduced by the administration of either haloperidol, a dopamine receptor blocker, or carbidopa, a peripheral blocker of dopa decarboxylase. This suggests that one peripheral action of dopamine is to modulate the action of aldosterone on the kidney. 2. No difference in urinary dopamine excretion after an 18 h fast was found in rats that had been either on a control diet or a high potassium diet. Both groups of rats responded by a similar elevation after an acute potassium load. This suggests that dopaminergic mediation of the enhanced response to aldosterone in rats on a chronic high potassium diet is not detectable by changes in urinary dopamine excretion. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：631 / 635

页数：5

共 15 条

[1] AMPLIFICATION OF ACTION OF ALDOSTERONE BY 5-ALPHA-DIHYDROCORTISOL [J].