RESISTANCE TO DOXORUBICIN IN TUMOR-CELLS INVITRO AND INVIVO AFTER PRETREATMENT WITH VERAPAMIL

被引：16

作者：

DONENKO, FV

EFFERTH, T

MATTERN, J

MOROZ, LV

VOLM, M

机构：

[1] Institute of Clinical Oncology, All-Union Cancer Research Center, Moscow

[2] Institute of Experimental Pathology, German Cancer Research Center, Heidelberg

来源：

CHEMOTHERAPY | 1991年 / 37卷 / 01期

关键词：

RESISTANCE; TUMOR CELLS; DOXORUBICIN; VERAPAMIL;

D O I：

10.1159/000238833

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Sarcoma 180 (S180) cells pretreated with verapamil increase their resistance to doxorubicin in vitro. This result could be confirmed by in vivo experiments using P388 cells. The mechanism for this resistance is different from the P-glycoprotein-mediated mechanism characteristic for multidrug-resistant cells.

引用

页码：57 / 61

页数：5

共 9 条

[1]

BACHUR NR, 1970, CANCER CHEMOTH REP 1, V54, P89

[2]

DETECTION OF P-GLYCOPROTEIN IN MULTIDRUG-RESISTANT CELL-LINES BY MONOCLONAL-ANTIBODIES [J].