学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审

INSTABILITY AND DECAY OF THE PRIMARY STRUCTURE OF DNA

被引：4510
作者：
LINDAHL, T
机构：
[1] Imperial Cancer Research Fund, Clare Hall Laboratories
来源：
NATURE | 1993年 / 362卷 / 6422期
关键词：
D O I：
10.1038/362709a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 [理学]; 0710 [生物学]; 09 [农学];
摘要：
Although DNA is the carrier of genetic information, it has limited chemical stability. Hydrolysis, oxidation and nonenzymatic methylation of DNA occur at significant rates in vivo, and are counteracted by specific DNA repair processes. The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils.
引用
收藏
页码：709 / 715
页数：7
相关论文
共 85 条
[1]
THE MECHANISM OF IRREVERSIBLE ENZYME INACTIVATION AT 100-DEGREES-C [J].
AHERN, TJ ;
KLIBANOV, AM .
SCIENCE, 1985, 228 (4705) :1280-1284
[2]
ARUOMA OI, 1989, J BIOL CHEM, V264
[3]
GROWTH OF BLACK SMOKER BACTERIA AT TEMPERATURES OF AT LEAST 250-DEGREES-C [J].
BAROSS, JA ;
DEMING, JW .
NATURE, 1983, 303 (5916) :423-426
[4]
NON-ENZYMATIC METHYLATION OF DNA BY S-ADENOSYLMETHIONINE INVITRO [J].
BARROWS, LR ;
MAGEE, PN .
CARCINOGENESIS, 1982, 3 (03) :349-351
[5]
GENETIC-EFFECTS OF THYMINE GLYCOL - SITE-SPECIFIC MUTAGENESIS AND MOLECULAR MODELING STUDIES - (IONIZING-RADIATION OXIDATIVE DAMAGE HYDROXYL RADICALS) [J].
BASU, AK ;
LOECHLER, EL ;
LEADON, SA ;
ESSIGMANN, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :7677-7681
[6]
MOLECULAR MECHANISMS OF OXYGEN RADICAL CARCINOGENESIS AND MUTAGENESIS - THE ROLE OF DNA-BASE DAMAGE [J].
BREIMER, LH .
MOLECULAR CARCINOGENESIS, 1990, 3 (04) :188-197
[7]
MODIFICATION OF DNA BY REDUCING SUGARS - A POSSIBLE MECHANISM FOR NUCLEIC-ACID AGING AND AGE-RELATED DYSFUNCTION IN GENE-EXPRESSION [J].
BUCALA, R ;
MODEL, P ;
CERAMI, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (01) :105-109
[8]
DETECTION AND CHARACTERIZATION BY P-32 POSTLABELING OF DNA ADDUCTS INDUCED BY A FENTON-TYPE OXYGEN RADICAL-GENERATING SYSTEM [J].
CARMICHAEL, PL ;
SHE, MN ;
PHILLIPS, DH .
CARCINOGENESIS, 1992, 13 (07) :1127-1135
[9]
ROLE OF URACIL-DNA GLYCOSYLASE IN MUTATION AVOIDANCE BY STREPTOCOCCUS-PNEUMONIAE [J].
CHEN, JD ;
LACKS, SA .
JOURNAL OF BACTERIOLOGY, 1991, 173 (01) :283-290
[10]
Cleaver JE, 1989, METABOLIC BASIS INHE, V6th, P2949
123456789