EMERGENCE OF FLUOROQUINOLONE-RESISTANT TUBERCULOSIS IN NEW-YORK-CITY

被引：107

作者：

SULLIVAN, EA

KREISWIRTH, BN

PALUMBO, L

KAPUR, V

MUSSER, JM

EBRAHIMZADEH, A

FRIEDEN, TR

机构：

[1] NEW YORK CITY DEPT HLTH,NEW YORK,NY 10013

[2] CTR DIS CONTROL & PREVENT,ATLANTA,GA 30341

[3] PUBL HLTH RES INST,CTR TB,NEW YORK,NY

[4] BAYLOR COLL MED,DEPT PATHOL,MOLEC PATHOBIOL SECT,HOUSTON,TX 77030

来源：

LANCET | 1995年 / 345卷 / 8958期

关键词：

D O I：

10.1016/S0140-6736(95)90980-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.

引用

页码：1148 / 1150

页数：3

共 10 条

[1] SELECTION OF A GYRA MUTANT OF MYCOBACTERIUM-TUBERCULOSIS RESISTANT TO FLUOROQUINOLONES DURING TREATMENT WITH OFLOXACIN [J].