BONE-MARROW TRANSPLANTATION FOR SEVERE APLASTIC-ANEMIA - REPORT OF 9 CASES

被引：13

作者：

MARMONT, AM ^{[1
]}

VANLINT, MT ^{[1
]}

AVANZI, G ^{[1
]}

REALI, G ^{[1
]}

ADAMI, R ^{[1
]}

SOLDA, A ^{[1
]}

STRADA, P ^{[1
]}

BARBANTI, M ^{[1
]}

MINGARI, MC ^{[1
]}

SORO, O ^{[1
]}

GRAZI, G ^{[1
]}

PEDULLA, D ^{[1
]}

CERRI, R ^{[1
]}

ROSSI, E ^{[1
]}

GIORDANO, D ^{[1
]}

SANTINI, G ^{[1
]}

CARELLA, A ^{[1
]}

RISSO, M ^{[1
]}

VIMERCATI, R ^{[1
]}

PIAGGIO, G ^{[1
]}

RAFFO, MR ^{[1
]}

LIBRACE, E ^{[1
]}

VITALE, V ^{[1
]}

BACIGALUPO, A ^{[1
]}

机构：

[1] OSPED GALLIERA, BLOOD BANK & TISSUE TYPING LAB, GENOVA, ITALY

来源：

ACTA HAEMATOLOGICA | 1979年 / 62卷 / 03期

关键词：

Aplastic anemia; Bone marrow transplantation;

D O I：

10.1159/000207557

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

9 patients with severe aplastic anemia (SAA) were treated with bone marrow transplantation (BMT). 5 were conditioned with cyclophosphamide and received and HLA-identical graft (4 patients) or a mismatched graft (1 patient): 1 rejected the graft on day 30 and died on day 34 during conditioning for a second transplant; 1 died on day 15 with acute and severe graft versus host disease (GvHD) in the absence of haemopoietic engraftment; 3 are alive and complete chimeras at 1,069, 490 and 332 days after transplantation. GvHD developed in 4 patients and was treated successfully in 3 with high dose methylprednisolone and/or antilymphocytic globulin (ALG). 4 patients were conditioned with ALG and received bone marrow from a haploidentical sibling or parent: 1 patient was refractory; 3 patients showed evidence of hematologic reconstitution, but 2 of these required a second course of ALG. 3 patients in this group are alive between 60 and 490 days; 1 patient died on day 121 of HBSAg-negative acute hepatitis. © 1979 S. Karger AG, Basel.

引用

页码：121 / 127

页数：7

共 20 条

[1]

BACIGALUPO A, 1979, NEW ENGL J MED, V300, P501

[2]

CAMITTA BM, 1976, BLOOD, V48, P63

[3]

GALE RP, 1977, BLOOD, V50, P185

[4]

GLUCKMAN E, 1975, NOUV PRESSE MED, V4, P1177

[5] BONE-MARROW TRANSPLANTATION IN CHILDREN WITH APLASTIC-ANEMIA AND ACUTE LYMPHATIC LEUKEMIA [J].

KOLB, HJ ;

WUNDISCH, GF ;

BENDERGOTZE, C ;

SPITZER, I ;

BREHM, G ;

RODT, H ;

LIEVEN, HV ;

GROSSEWILDE, H ;

ALBERT, ED ;

THIEL, E ;

RUPPELT, W ;

BALK, O ;

THIERFELDER, S .

BLUT, 1975, 31 (06) :343-346

[6]

MARMONT A, 1977, BLOOD, V49, P155

[7] A TO O BONE-MARROW TRANSPLANTATION IN SEVERE APLASTIC-ANEMIA - DYNAMICS OF BLOOD-GROUP CONVERSION AND DEMONSTRATION OF EARLY DYSERYTHROPOIESIS IN ENGRAFTED MARROW [J].

MARMONT, AM ;

DAMASIO, EE ;

BACIGALUPO, A ;

GIORDANO, D ;

ROSSI, E ;

REALI, G ;

GAY, A ;

DAGNABRICARELLI, F ;

BREMA, F ;

CARELLA, AM ;

SANTINI, G .

BRITISH JOURNAL OF HAEMATOLOGY, 1977, 36 (04) :511-518

[8]

MARMONT AM, 1979, NOUV REV FR HEMATOL, V21, P133

[9]

MARMONT AM, 1978, NOUV PRESSE MED, V7, P2406

[10]

MATHE G, 1976, EXP HEMATOL, V4, P256

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