ACROMELIC ACID-C - A NEW TOXIC CONSTITUENT OF CLITOCYBE-ACROMELALGA - AN EFFICIENT ISOLATION OF ACROMELIC ACIDS

被引:39
作者
FUSHIYA, S
SATO, S
KANAZAWA, T
KUSANO, G
NOZOE, S
机构
[1] Pharmaceutical Institute, Tohoku University, Sendai, 980, Aobayama
关键词
D O I
10.1016/S0040-4039(00)97501-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The neurotoxic amino acids, acromelic acids A and B were efficiently isolated from the poisonous mushroom Clitocybe acromelalga, accompanied by a new toxic analogue, acromelic acid C. The structure of acromelic acid C was elucidated to be 1 by comparison of the spectral data with those of acromelic acids A and B. Acromalic acid C exhibited a lethal toxicity to the mice at a dose of 10 mg/kg. © 1990.
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页码:3901 / 3904
页数:4
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