ULTRAVIOLET-IRRADIATION INHIBITS RNA DECAY AND MODIFIES RIBOSOMAL-RNA PROCESSING IN TRYPANOSOMA-BRUCEI

被引：29

作者：

COQUELET, H ^{[1
]}

STEINERT, M ^{[1
]}

PAYS, E ^{[1
]}

机构：

[1] UNIV BRUSSELS,DEPT MOLEC BIOL,67 RUE CHEVAUX,B-1640 RHODE ST GENESE,BELGIUM

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1991年 / 44卷 / 01期

关键词：

D O I：

10.1016/0166-6851(91)90218-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A known effect of ultraviolet radiation on transcription is the arrest of RNA elongation. In Trypanosoma brucei, we show that UV also inhibits RNA decay, leading to specific accumulation of transcripts from the beginning of several transcription units. In addition, UV irradiation changes the pattern of ribosomal RNA processing, probably by altering the order in which the non-coding spacers are excised. These effects are still observed on RNA synthesized more than 2 h after irradiation, and do not depend on protein synthesis. © 1991.

引用

页码：33 / 42

页数：10

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