RELATIONSHIP BETWEEN ANTIBODIES TO DSDNA AND TO SOLUBLE CELLULAR ANTIGENS AND HISTOLOGICALLY DEFINED GLOMERULONEPHRITIS IN PATIENTS WITH SLE

被引：1

作者：

ASERO, R ^{[1
]}

BANFI, G ^{[1
]}

RADELLI, L ^{[1
]}

ORIGGI, L ^{[1
]}

BERTETTI, E ^{[1
]}

VANOLI, M ^{[1
]}

RIBOLDI, P ^{[1
]}

机构：

[1] POLITECN MILAN,DIV NEFROL & DIALISI,I-20133 MILAN,ITALY

来源：

AUTOIMMUNITY | 1990年 / 7卷 / 01期

关键词：

Complement; DsDNA antibody; Glomerulonephritis; Soluble cellular antigens; Systemic lupus erythematosus;

D O I：

10.3109/08916939009041046

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To better define the relationships between circulating autoantibodies and renal involvement in systemic lupus erythematosus (SLE), antibodies to both dsDNA and soluble cellular antigens were detected in sera from a large series of SLE patients. Significantly higher dsDNA binding activities and lower complement levels at onset were found in patients with renal disease; however, this was uniquely due to subjects with diffuse or focal proliferative glomerulonephritis. Patients with membranous nephropathy (MGN) showed very low dsDNA binding activities (6/9 of them being negative for dsDNA antibodies) and normal mean C3 and C4 levels. A comparison between patients with proliferative nephritis and patients without renal involvement with high dsDNA binding activities revealed significantly lower complement levels in the former group. No significant difference was observed in the prevalence of antibodies to soluble cellular antigens between patients with or without renal disease; however, nRNP antibody was two-fold more frequent in patients with MGN than in all other subgroups. This study highlights the close relationship between concurrently high anti-dsDNA and low complement levels and proliferative glomerulonephritis in SLE, and suggests that subjects with MGN may represent a subgroup of SLE patients showing peculiar serological features. Different mechanisms possibly involved in the pathogenesis of MGN in SLE are discussed. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：13 / 21

页数：9

共 25 条

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