MODEL GENOMES - THE BENEFITS OF ANALYZING HOMOLOGOUS HUMAN AND MOUSE SEQUENCES

被引：9

作者：

HOOD, L

KOOP, B

GOVERMAN, J

HUNKAPILLER, T

机构：

[1] L. Hood, B. Koop, J. Goverman and T. Hunkapiller are at the NSF Science and Technology Center for Molecular Biotechnology, Division of Biology, California Institute of Technology, Pasadena

来源：

TRENDS IN BIOTECHNOLOGY | 1992年 / 10卷 / 1-2期

关键词：

D O I：

10.1016/0167-7799(92)90161-N

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The human genome initiative has provided the motivating force for launching sequencing projects suitable for testing various DNA-sequencing strategies, as well as motivating the development of mapping and sequencing technologies. In addition to projects targeting selected regions of the human genome, other projects are based on model organisms such as yeast, nematode and mouse. The sequencing of homologous regions of human and mouse genomes is a new approach to genome analysis, and is providing insights into gene evolution, function and regulation which could not be determined so easily from the analysis of just one species.

引用

页码：19 / 22

页数：4

共 8 条

[1] T-CELL RECEPTOR GENE DIVERSITY AND SELECTION [J].

DAVIS, MM .

ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 :475-496

[2]

HOOD LE, 1984, IMMUNOLOGY

[3] LARGE-SCALE AND AUTOMATED DNA-SEQUENCE DETERMINATION [J].

HUNKAPILLER, T ;

KAISER, RJ ;

KOOP, BF ;

HOOD, L .

SCIENCE, 1991, 254 (5028) :59-67

[4] LARGE-SCALE DNA SEQUENCING [J].

HUNKAPILLER, T ;

KAISER, RJ ;

KOOP, BF ;

HOOD, L .

CURRENT OPINION IN BIOTECHNOLOGY, 1991, 2 (01) :92-101

[5]

HUNKAPILLER T, 1990, SPR COLD HARB S QUAN, V54, P15

[6] PHYSICAL MAPS OF THE MOUSE AND HUMAN IMMUNOGLOBULIN-LIKE LOCI [J].

LAI, E ;

WILSON, RK ;

HOOD, LE .

ADVANCES IN IMMUNOLOGY, 1989, 46 :1-59

[7] MAPS OF LINKAGE AND SYNTENY HOMOLOGIES BETWEEN MOUSE AND MAN [J].

NADEAU, JH .

TRENDS IN GENETICS, 1989, 5 (03) :82-86

[8] GENOME CENTER GRANTS CHOSEN [J].

ROBERTS, L .

SCIENCE, 1990, 249 (4976) :1497-1497

← 1 →